Biology – E JEMED http://e-jemed.org/ Sat, 25 Sep 2021 10:54:57 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://e-jemed.org/wp-content/uploads/2021/05/default1-150x150.png Biology – E JEMED http://e-jemed.org/ 32 32 Biology will now be part of the engineering curriculum. Here’s why – Edexlive https://e-jemed.org/biology-will-now-be-part-of-the-engineering-curriculum-heres-why-edexlive/ https://e-jemed.org/biology-will-now-be-part-of-the-engineering-curriculum-heres-why-edexlive/#respond Sat, 25 Sep 2021 10:31:00 +0000 https://e-jemed.org/biology-will-now-be-part-of-the-engineering-curriculum-heres-why-edexlive/ All engineering schools at Visvesvaraya Technological University (VTU) will offer “Biology for Engineers” as a subject from this year. It will be part of the “capacity improvement courses” under the National Education Policy (NEP). Explaining the new addition to all of this year’s engineering courses, VTU Vice Chancellor Karisiddappa told TNIE that in the context […]]]>

All engineering schools at Visvesvaraya Technological University (VTU) will offer “Biology for Engineers” as a subject from this year. It will be part of the “capacity improvement courses” under the National Education Policy (NEP).

Explaining the new addition to all of this year’s engineering courses, VTU Vice Chancellor Karisiddappa told TNIE that in the context of COVID-19, engineers have been seen working closely with medics to design medical equipment, using advanced technologies such as artificial neurons, highlighting the need for the concept of biology in engineering courses.

The curriculum is in development, and the subject will be introduced for sophomores as well, so it helps those who want to gain lateral entry into engineering. This will include the study of cells and blood flow, and it is also necessary to understand the nervous system while working with artificial neural networks.

Besides “Biology for Engineers” as a capability improvement course, blockchain technology and data analysis and simulations should also be added to the curriculum, Karisiddappa said. The introduction of biology will be seen as the first iteration of the policy, with the aim of making the education system self-sufficient. Colleges should think about opening new departments considered multidisciplinary, he added.

66 colleges to award a basic science degree

Engineering schools will use their teaching capacities – quality of teachers, availability of laboratories and classrooms – to introduce basic science courses. Physics, chemistry and mathematics will now be taught by teachers in engineering courses, Vice Chancellor Karisiddappa told TNIE. He said the colleges, which are mostly private, assisted, and autonomous, were chosen based on their existing facilities, faculty members, and their accreditation by the National Board of Accreditation (NBA) and NAAC.

The merger of campuses to bring in professors from a scientific college from the same city or company (which manages the college of engineers) will be authorized. Faculty can be used from science colleges where the workload is less. This also comes against the background of the over 50 percent vacancy in SUV admissions. Karisiddappa said the reason the course started was to use the engineering faculty to teach physics, chemistry and mathematics; and the use of engineering college laboratories and facilities.


Source link

]]>
https://e-jemed.org/biology-will-now-be-part-of-the-engineering-curriculum-heres-why-edexlive/feed/ 0
Peru to focus on its biological and cultural megadiversity at Expo 2020 Dubai https://e-jemed.org/peru-to-focus-on-its-biological-and-cultural-megadiversity-at-expo-2020-dubai/ https://e-jemed.org/peru-to-focus-on-its-biological-and-cultural-megadiversity-at-expo-2020-dubai/#respond Fri, 24 Sep 2021 19:32:00 +0000 https://e-jemed.org/peru-to-focus-on-its-biological-and-cultural-megadiversity-at-expo-2020-dubai/ Lima, Peru – (COMMERCIAL THREAD) – In order to position Peru as a multicultural and megadiverse country with ancestral knowledge projected into the future, the Commission for the Promotion of Export and Tourism – PROMPERÚ convened the MEPs and SMEs of the industry of the export and tourism belonging to the 25 regions of Peru […]]]>

Lima, Peru – (COMMERCIAL THREAD) – In order to position Peru as a multicultural and megadiverse country with ancestral knowledge projected into the future, the Commission for the Promotion of Export and Tourism – PROMPERÚ convened the MEPs and SMEs of the industry of the export and tourism belonging to the 25 regions of Peru be part of the Peruvian trade pavilion at Expo 2020 Dubai. The objective is to promote the culture of the country, its biodiversity and, thus, generate business opportunities for the economic reactivation of export, tourism and investment zones.

The Peruvian presence will be reinforced by trade days dedicated to our different regions such as Expo Perú Los Andes (Los Andes Peru Expo), Expoamazónica (Amazonian Expo), Expo Perú Norte (North Peru Expo), and Sur Exporta (South Exports) which promote the export and tourism potential, as well as the cultural, tourist, historical and culinary wealth of all regions of the country. Of the 200 Peruvian companies expected, more than eighty percent will be MSEs and SMEs.

Peru’s participation will be aligned with the three pillars of Expo 2020 Dubai: “Opportunity”, “Sustainability” and “Mobility”. The commercial aspect will be linked to the protection of the environment and biodiversity, as well as the preservation of culture, issues of the utmost importance for Peru and the world.

The official delegation and regional governments will submit portfolios of investment projects to potential investors. The regional supply of goods and services and the portfolios of tourism projects will be essential to open up new markets in the Middle East and stimulate Peru’s internationalization process.

In each of the events dedicated to the regions, we will have the participation and exhibition of exportable products, the exhibition of the routes and tourist attractions of the regions, as well as business meetings with potential buyers. In addition, cultural activities, dance and music from each of the regions will be presented by the regional governments.

It is worth highlighting the coordination work carried out between PROMPERÚ, the regional communities of Los Andes and the Macro Northeast Region of Peru, the southern regions, as well as the Interregional Council of the Amazon (Consejo Interregional Amazónico, CIAM), in order to prioritize the participation of MEPs from all over the country.

Enjoy the Expo 2020 Dubai experience by registering here: https://media.expo2020dubai.com/.


Source link

]]>
https://e-jemed.org/peru-to-focus-on-its-biological-and-cultural-megadiversity-at-expo-2020-dubai/feed/ 0
Tension between structured complexes and disordered assemblages https://e-jemed.org/tension-between-structured-complexes-and-disordered-assemblages/ https://e-jemed.org/tension-between-structured-complexes-and-disordered-assemblages/#respond Fri, 24 Sep 2021 05:23:02 +0000 https://e-jemed.org/tension-between-structured-complexes-and-disordered-assemblages/ How are the many metabolic pathways and biochemical functions of cells spatially organized? In his early ideas on cell organization, Edmund Wilson said that cells are filled with liquid (and by definition messy) coacervates. Think of the oil droplets in vinegar. Then, membrane organelles and structured complexes were discovered and took over thanks to the […]]]>

How are the many metabolic pathways and biochemical functions of cells spatially organized? In his early ideas on cell organization, Edmund Wilson said that cells are filled with liquid (and by definition messy) coacervates. Think of the oil droplets in vinegar. Then, membrane organelles and structured complexes were discovered and took over thanks to the flourishing discipline of structural biology.

Recently, coacervates have found their way back into the narrative and are now known as membraneless organelles or biomolecular condensates. They largely compartmentalize cells without membranes, and phase separation shapes many fundamental biological processes. Therefore, deregulation of phase separation can lead to disease. But the pendulum has pulled back too far, and protein haze is now often described as a key ingredient needed for phase separation.

The highly structured complexes and internal structure of biomolecular condensates are not getting the attention they deserve. In our theme, we will highlight the spectrum between ordered molecular machines with precise stoichiometry and non-stoichiometric condensates, the latter possibly being completely disordered or having a more defined lattice structure. Both are necessary and shape the functions of our cells.

Key words: molecular mechanisms, structural biology, biophysics, soft matter physics

Who should be present: all those who like molecular mechanisms and are not afraid of a little mess

Theme song: Anything by Rage Against the Machine – or the Droplettes (just kidding)

This session is powered by dressing and other immiscible fluids.

Talks

  • In situ structural analysis of the nuclear porous complex – Martin beck, Max Planck Institute for Biophysics
  • Molecular-scale structure of a highly curved membrane – Adam frost, University of California, San Francisco
  • Structure and function of DNA transposition assemblies – Orsolya Barabas, University of Geneva
  • Structural adventures in bacterial protein secretion and motility – Susan lea, National Institutes of Health
  • Building the microtubule cytoskeleton via phase transitions – Sabine petry, Princeton University
  • Structured and disordered proteins collaborate to drive membrane remodeling – Jeanne Stachowiak, University of Texas at Austin
  • Understand how oncogenic fusion proteins cause aberrant gene expression through phase separation – Richard kriwacki, St. Jude Children’s Research Hospital
  • Deciphering the plasticity of the black proteome – Edouard Lemke, Johannes Gutenberg University and Institute of Molecular Biology
  • Phase behavior of inherently disordered prion-like domains – Tanja Mittag, St. Jude Children’s Research Hospital
  • Regulation of translation and deadenylation via biomolecular condensates – Julie Forman – Kay, Hospital for sick children
  • Effects of polyubiquitin on phase transitions of the UBQLN2 shuttle protein – Carlos Castañeda, Syracuse University
  • The role of phase transitions in transcription – Ibrahim Cisse, California Institute of Technology

Learn more

Discover the ten thematic symposia planned for the ASBMB 2022 annual meeting:

  • Diversity, equity and inclusion
  • Protein machines and mess
  • Signage
  • Quality control of organelles
  • Metabolism
  • Enzymology
  • RNA / DNA
  • Membranes / lipids
  • Glycobiology
  • Education and Professional Development

(Hyperlinks will be added as these articles are posted on the ASBMB Today website. You can also visit the ASBMB Annual Meeting page.)


Source link

]]>
https://e-jemed.org/tension-between-structured-complexes-and-disordered-assemblages/feed/ 0
L7 Informatics Signs Agreement with ATCC, a Leading Biological Materials Company https://e-jemed.org/l7-informatics-signs-agreement-with-atcc-a-leading-biological-materials-company/ https://e-jemed.org/l7-informatics-signs-agreement-with-atcc-a-leading-biological-materials-company/#respond Thu, 23 Sep 2021 14:18:00 +0000 https://e-jemed.org/l7-informatics-signs-agreement-with-atcc-a-leading-biological-materials-company/ AUSTIN, Texas, September 23, 2021 / PRNewswire / – L7 Informatics, a leader in enterprise-wide digital transformation and science process automation in the life sciences, announced it will begin collaborating with ATCC to help improve the digitization of its manufacturing and laboratory operations. ATCC, a leading global organization for resources and information on biological materials […]]]>

AUSTIN, Texas, September 23, 2021 / PRNewswire / – L7 Informatics, a leader in enterprise-wide digital transformation and science process automation in the life sciences, announced it will begin collaborating with ATCC to help improve the digitization of its manufacturing and laboratory operations. ATCC, a leading global organization for resources and information on biological materials and standards, will work with L7 | ESP to assess the benefits of its platform to determine feasibility in its manufacturing environment.

L7 | ESP is a unified, composable platform with a single data structure that reduces total cost of operations while enabling digital transformation of biological operations including research, process development, clinical operations, manufacturing and quality control. This FDA-compliant platform comes with several pre-built, best-in-class apps. In addition, L7 | ESP’s REST API library and Python SDK allow flexibility and extensibility to meet specific customer requirements.

L7 Informatics continually adds new applications with each release. Gartner recently recognized L7 as a cool provider in life sciences, an example of a cell and gene therapy platform provider in eight different Hype Cycle reports, and highlighted L7 | ESP for biologics manufacturing markets. , quality control and molecular diagnostics in a recent Market Guide for Computer Laboratories.

“ATCC offers the world’s largest and most diverse collection of biological research solutions, and they are a leader in biological and published laboratory standards. L7 | ESP, with its unique technical strength and flexibility, is delighted with the opportunity to collaborate with ATCC on its current workflow needs and future distribution of standards, ”said Trent carrier, Ph.D., MBA, Director of Operations at L7 Informatics.

About L7 Informatique

At L7 Informatics, Inc., our mission is to revolutionize scientific processes and data management to accelerate precision health in the life sciences, healthcare and nutrition value chains.

Our end-to-end solutions and services enable researchers to make new discoveries in genomics, manufacturers of precision therapeutics to create higher fidelity therapies, healthcare systems to deliver superior diagnostics and standards of care, and precision agriculture to meet the needs of tomorrow.

SOURCE L7 Computer Science

Related links

l7informatics.com


Source link

]]>
https://e-jemed.org/l7-informatics-signs-agreement-with-atcc-a-leading-biological-materials-company/feed/ 0
Univar Solutions and Novozymes to provide biological solutions for waste and wastewater treatment – Chemical Engineering https://e-jemed.org/univar-solutions-and-novozymes-to-provide-biological-solutions-for-waste-and-wastewater-treatment-chemical-engineering/ https://e-jemed.org/univar-solutions-and-novozymes-to-provide-biological-solutions-for-waste-and-wastewater-treatment-chemical-engineering/#respond Wed, 22 Sep 2021 20:17:17 +0000 https://e-jemed.org/univar-solutions-and-novozymes-to-provide-biological-solutions-for-waste-and-wastewater-treatment-chemical-engineering/ By Mary Page Bailey | September 22, 2021 Univar Solutions Inc. (Downers Grove, Illinois), a global distributor of chemicals and ingredients and provider of value-added services, announced a new agreement with Novozymes A / S (Copenhagen, Denmark), expanding its relationship to include biological solutions for the treatment of waste and wastewater in the United States […]]]>

By Mary Page Bailey |

Univar Solutions Inc. (Downers Grove, Illinois), a global distributor of chemicals and ingredients and provider of value-added services, announced a new agreement with Novozymes A / S (Copenhagen, Denmark), expanding its relationship to include biological solutions for the treatment of waste and wastewater in the United States and Canada. Longtime global partners, the new agreement follows previous announcements extending the partnership to a range of markets in the United States, Canada and Latin America.

“We are delighted to expand our partnership with Novozymes and add to our market-leading and more sustainable wastewater treatment capabilities. Our customers have complex water treatment requirements and rely on us for their products and chemicals, as well as exceptional service and deep industry expertise. Adding Novozymes’ specialty biological solutions to our wastewater treatment portfolio strengthens our offerings and enables us to provide customers with essential and sustainable products and services to help meet vital business needs, ”said Brian Jurcak, vice -President of product marketing management at Univar. Solutions. “Investing in our water treatment business and improving it with the best-in-class bioaugmentation products allows our dedicated water treatment team, led by renowned industry expert John Fulcher, to continue. to provide reliable and next-generation solutions for our customers. “

“This partnership will help Novozymes expand our reach within the water industry through Univar Solutions’ vast network of industry experts – and Univar Solutions has truly done an outstanding job growing its team and its network of clients and relationships, ”added Brian Brazeau, Novozymes’ President for North America and Vice President, Agriculture and Industrial Biosolutions, Americas. “With biology and biotechnology increasingly recognized as catalysts for the next industrial revolution, this partnership will help initiate a fundamental shift towards more sustainable biological solutions, also in the water and waste industries. “

The new agreement strengthens Univar Solutions’ ability to serve municipal and industrial wastewater treatment plants, providing bioaugmentation, biogas and enzymatic sludge management and microbial treatment solutions. Novozymes’ biological solutions in enzymatic and microbial technology catalyze key processes, for example transforming organic matter dissolved in wastewater into biomass that can be separated from treated wastewater and safely disposed of. Cutting-edge biotechnology enables biological solutions to traditional challenges in water and waste treatment such as sludge management, degradation of recalcitration compounds and biogas production.

waste and sewage treatment in the United States and Canada. Longtime global partners, the new agreement follows previous announcements extending the partnership to a range of markets in the United States, Canada and Latin America.


Source link

]]>
https://e-jemed.org/univar-solutions-and-novozymes-to-provide-biological-solutions-for-waste-and-wastewater-treatment-chemical-engineering/feed/ 0
OU student Sarah Denha visits the marine biology lab – The Oakland Post https://e-jemed.org/ou-student-sarah-denha-visits-the-marine-biology-lab-the-oakland-post/ https://e-jemed.org/ou-student-sarah-denha-visits-the-marine-biology-lab-the-oakland-post/#respond Wed, 22 Sep 2021 13:06:13 +0000 https://e-jemed.org/ou-student-sarah-denha-visits-the-marine-biology-lab-the-oakland-post/ As reported by Oakland University News, Sarah Denha ‒‒ an OU doctoral student studying biomedical sciences ‒‒ traveled to Massachusetts over the summer to participate in one of the Marine biology laboratory (MBL) courses in neurobiology. Iraqi by birth, Denha immigrated with her family to the United States in 2013. Denha lived in California for […]]]>

As reported by Oakland University News, Sarah Denha ‒‒ an OU doctoral student studying biomedical sciences ‒‒ traveled to Massachusetts over the summer to participate in one of the Marine biology laboratory (MBL) courses in neurobiology.

Iraqi by birth, Denha immigrated with her family to the United States in 2013. Denha lived in California for a year where she received her GED degree, before moving to Michigan in 2014 and enrolling at Macomb Community College. shortly after. She was then transferred to OU where she obtained a bachelor’s degree in biochemistry.

Five years later, she enrolled in the OU’s master’s program in chemistry, and in 2020 she changed her field of study to biomedical sciences. It was after this flurry of academic decisions that Denha found herself able to participate in the MBL course entitled “Neurobiology: Mechanisms and Advanced Approaches”. A five-week course, Denha was one of 18 selected students who collected data, conducted experiments and presented their work in various neurobiological fields.

Having received funding from WHERE and the Grass Foundation ‒‒ a non-profit foundation focused on facilitating neuroscience research ‒‒ Denha also discussed the importance of the biochemistry professor OR that of Dr. Adam Avery help in developing their academic goals.

“I had no research experience (before graduate school), but with the mentorship and one-on-one interaction from Dr. Avery, I learned quickly,” Denha told Oakland University News. “I gained so much confidence in myself and in a year, I presented my work [on spinocerebellar ataxia type 5] at the American Society for Cell Biology International Conference. I did virtual conferences during COVID and met other people interested in my area of ​​research. Dr Avery encouraged me to apply for the Marine Biology Lab course which helped me make more connections and see opportunities after my PhD was completed.

Denha and Dr Avery have worked together outside of their research on type 5 spinocerebellar ataxia ‒‒ Denha was featured as a co-author of the Avery article published in 2021 in the Journal of Biological Chemistry.

In the MBL course taught by professors at Yale University and UC Berkeley ‒‒ which also had a guest lecture Zoom from the 2003 Nobel laureate in chemistry Roderick MacKinnon ‒‒ Avery believed Denha had found experiences that had a positive impact on her development as a person and as an academic.

“Sarah has been a great achievement,” Dr. Avery told Oakland University News. “She worked hard and took the opportunities to grow in her field. I think being accepted into an exclusive high caliber program like the MBL course really shows your potential as a scientist. She was fortunate to learn from the best scientists in the world and walked away with a renewed sense of identity and purpose. “

With works ranging from NIH– from funded reviews of the effect of spinocerebellar ataxia type 5 on genetic mutations to experiments using electrophysiology to perform electrical field recording of neurons in the hippocampus of a mouse, Denha is drawn to university life wholeheartedly. The pursuit of gaining a more complete understanding of the molecular foundations of neurological diseases is what motivates her.

“I like the novelty of the research,” Denha said. “I like the challenge of looking at the data and trying to figure out what it means. And I love knowing that my work has the power to positively impact people’s lives.


Source link

]]>
https://e-jemed.org/ou-student-sarah-denha-visits-the-marine-biology-lab-the-oakland-post/feed/ 0
Smithsonian National Zoo lions and tigers test presumably positive for COVID-19 https://e-jemed.org/smithsonian-national-zoo-lions-and-tigers-test-presumably-positive-for-covid-19/ https://e-jemed.org/smithsonian-national-zoo-lions-and-tigers-test-presumably-positive-for-covid-19/#respond Tue, 21 Sep 2021 20:04:24 +0000 https://e-jemed.org/smithsonian-national-zoo-lions-and-tigers-test-presumably-positive-for-covid-19/ To combat the 9 lions and tigers showing signs of SARS-CoV-2, zoo officials are keeping a close eye on cats by managing their access to outdoor habitats, providing anti-inflammatory and anti-nausea medications, and more. Officials at the Smithsonian National Zoo & Conservation Biology Institute in Washington, DC, announced that 6 African lions, 2 Amur tigers […]]]>

To combat the 9 lions and tigers showing signs of SARS-CoV-2, zoo officials are keeping a close eye on cats by managing their access to outdoor habitats, providing anti-inflammatory and anti-nausea medications, and more.

Officials at the Smithsonian National Zoo & Conservation Biology Institute in Washington, DC, announced that 6 African lions, 2 Amur tigers and 1 Sumatran tiger had tested positive for SARS-CoV-2.

According to a statement from the organization, animal keepers began to notice a decrease in appetite, lethargy, sneezing and coughing in several lions and tigers. Staff chose to take stool samples from the 9 animals that tested suspected positive for COVID-19. The final results are expected in the coming days.

To combat the discomfort and decreased appetite, all lions and tigers are currently being treated with anti-inflammatory and anti-nausea medications as well as antibiotics for suspected secondary bacterial pneumonia.

Since the condition does not require the animals to stay outdoors, staff will monitor them closely and regulate the cats’ access to their habitats. Considering the great distance between animals and visitors, the public is not in danger. So far, no other animal in the zoo is showing signs of infection.

The zoo has launched an investigation of all staff who were in the vicinity of the lions and tigers, and according to the statement, “there is no evidence to identify the source of the infection.” Although it is possible that the infection was transmitted by an asymptomatic carrier, it is routine for all animal care and essential personnel to wear masks indoors in all public and non-public spaces. .

Although the United States Department of Agriculture has cleared the use of the SARS-CoV-2 vaccine specially designed for zoo animals by Zoetis, the first round of vaccine disbursements will be administered to select animals susceptible to the virus at the Zoo and at the Conservation Biology Institute in Virginia in the coming months when it becomes available. All zoo staff continue to strictly enforce their COVID-19 protocols.

The references

Smithsonian National Institute of Zoo and Conservation Biology. Large cats have tested presumed positive for COVID-19 at the Smithsonian National Zoo. Nationalzoo.si.edu. Posted September 17, 2021. Accessed September 21, 2021. https://nationalzoo.si.edu/news/great-cats-tested-presumptive-positive-for-covid-19-smithsonians-national-zoo


Source link

]]>
https://e-jemed.org/smithsonian-national-zoo-lions-and-tigers-test-presumably-positive-for-covid-19/feed/ 0
Marine biologist Kevin Lewand has never taken the ocean for granted and made it his playground and his career. | Face to face https://e-jemed.org/marine-biologist-kevin-lewand-has-never-taken-the-ocean-for-granted-and-made-it-his-playground-and-his-career-face-to-face/ https://e-jemed.org/marine-biologist-kevin-lewand-has-never-taken-the-ocean-for-granted-and-made-it-his-playground-and-his-career-face-to-face/#respond Tue, 21 Sep 2021 07:00:00 +0000 https://e-jemed.org/marine-biologist-kevin-lewand-has-never-taken-the-ocean-for-granted-and-made-it-his-playground-and-his-career-face-to-face/ Everything about Kevin Lewand’s appearance is marked by the sun. Her blonde hair is messy and bleached from the sun, her tan is one that never fades. Even her little house in Monterey smells of sea water and sand; dozens of cookbooks in the kitchen speak of his love for seafood. The first thing that […]]]>

Everything about Kevin Lewand’s appearance is marked by the sun. Her blonde hair is messy and bleached from the sun, her tan is one that never fades. Even her little house in Monterey smells of sea water and sand; dozens of cookbooks in the kitchen speak of his love for seafood. The first thing that strikes a visitor is the dreamlike treehouse Lewand built for his daughter in the front yard. She’s a teenager now and the treehouse is mostly secluded, but they both love to surf and often do it together. The second thing that strikes a visitor is the amount of surfboards around the house.

Hailing from Santa Monica, Lewand, 52, is a Californian kid who has always been around water. Before joining the Monterey Bay Aquarium 20 years ago as a collector, he attended school in Santa Barbara and San Diego and studied marine biology and hydrobiology. Now he’s “taking stuff in the ocean” for the Monterey Bay Aquarium. He collects whatever they assign to him – mahi mahi, tuna, jellyfish, plankton. Most are samples for scientific research.

It wasn’t always the plan. When Lewand was 19, he met a surfer in San Diego who told him he was going to Bali and asked if Lewand wanted to go. “Damn yeah” was the only logical answer. The guy was a doctor – exactly what Lewand wanted to do with his life at the time. In Bali he met Australians and thanks to them he found work on a boat that sailed between Java and Zimbabwe and that was his summer job at university.

Weekly: While being a marine biologist in Monterey isn’t a total rarity, it’s a job kids often dream of, almost as much as being a soccer player. What’s your story?

Lewand: It was more of a fluke. At that time, I had just graduated from college and thought I was going to medical school. For fun, I used to love surfing and love being around the ocean, no doubt, but I didn’t really think I would do what I’m doing today. Never had a passion for aquariums. Some kids know this right away and want to work with dolphins and whales, but I had no idea.

What brought you to Monterey?

For a few years my plan was to join the Peace Corps and work in the fishery. They were going to take me to Africa, but eventually all places resisted. Lots of work at the university, at night, bartender, waiters at tables, trying to pay for school. I had a lot of student loans and was looking for a part-time job. I also had a lot of experience in scuba diving. So I started working for the San Francisco Aquarium and going underwater. Some people say they like to be in the water, but that’s not true. It has always been easy for me. I swam with white sharks near the Farallon Islands. Then I worked in San Diego, then Monterey got a job.

What would happen if you stayed a few days away from the ocean?

Do you want me to get cranky? Don’t get me wrong, I love to see the world, I just prefer to see the world with the ocean next to it. It feels good to see the ocean everyday. The funny thing is that my parents are from Ohio; I can’t even imagine… I never took the ocean for granted and I’ve always been to cool places around the world that are near the ocean. Covid has been a drag. I go to Bali every year during the full moon in May, but now it’s difficult. We were to be in Madagascar this summer.

What did you do instead?

I visited some places in eastern Oregon and eastern Washington. Did I like it? Yes. But I didn’t like him.

Can you identify the best place in the world to surf?

Everyone has their beaches. There are a few places for me. There is the palace I was talking about in Bali. In fact, it’s on Java. They call it G-Land. You leave Bali on the boat and it takes forever as the people, who take care of the surfers, stop to pray. Sometimes I go there during Ramadan, and it’s hard to watch people work. When you arrive you are in the jungle. You sleep in a hut and there are monkeys everywhere. There are no supermarkets. It is as if you have left your normal madness of the world. Indonesian food is very good and some of the best beaches are there. Another place is Fiji, but it is a bit more expensive for a surfer. But the waves are still beautiful.

So what’s your favorite aquatic activity?

Surfing, no doubt. I would surf until I died.


Source link

]]>
https://e-jemed.org/marine-biologist-kevin-lewand-has-never-taken-the-ocean-for-granted-and-made-it-his-playground-and-his-career-face-to-face/feed/ 0
RNA targeting enzyme extends CRISPR toolkit https://e-jemed.org/rna-targeting-enzyme-extends-crispr-toolkit/ https://e-jemed.org/rna-targeting-enzyme-extends-crispr-toolkit/#respond Mon, 20 Sep 2021 19:42:38 +0000 https://e-jemed.org/rna-targeting-enzyme-extends-crispr-toolkit/ McGovern fellows Jonathan Gootenberg (left) and Omar Abudayyeh in their lab. Credit: Caitlin Cunningham Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they believe could extend scientists’ CRISPR toolkit, making it easier to cut and edit RNA with the kind of precision that until ‘now was only available for […]]]>

McGovern fellows Jonathan Gootenberg (left) and Omar Abudayyeh in their lab. Credit: Caitlin Cunningham

Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they believe could extend scientists’ CRISPR toolkit, making it easier to cut and edit RNA with the kind of precision that until ‘now was only available for DNA editing. The enzyme, called Cas7-11, modifies RNA targets without damaging cells, suggesting that in addition to being a valuable research tool, it provides a fertile platform for therapeutic applications.

“This new enzyme is like the Cas9 of RNA,” says McGovern scholar Omar Abudayyeh, referring to the DNA-cleaving enzyme CRISPR that has revolutionized modern biology by making DNA editing fast, little expensive and accurate. “It creates two precise cuts and doesn’t destroy the cell in the process like other enzymes,” he adds.

So far, only one other family of RNA targeting enzymes, Cas13, has been extensively developed for RNA targeting applications. However, when Cas13 recognizes its target, it destroys all the RNAs in the cell, destroying the cell along the way. Like Cas9, Cas7-11 is part of a programmable system; it can be directed to specific RNA targets using a CRISPR guide. Abudayyeh, McGovern Fellow Jonathan Gootenberg and their colleagues discovered Cas7-11 through extensive exploration of CRISPR systems found in the microbial world. Their findings were recently published in the journal Nature.

Explore natural diversity

Like other CRISPR proteins, Cas7-11 is used by bacteria as a defense mechanism against viruses. After encountering a new virus, bacteria that use the CRISPR system keep a record of the infection in the form of a small extract of the pathogen’s genetic material. If this virus reappears, the CRISPR system is activated, guided by a small piece of RNA to destroy the viral genome and clear the infection.

These ancient immune systems are widespread and diverse, with different bacteria deploying different proteins to counter their viral invaders.

“Some target DNAs, some target RNAs. Some are very good at cleaving the target but have some toxicity, and some don’t. They introduce different types of cuts, they can differ in specificity, and so on,” says Eugene. Koonin, an evolutionary biologist at the National Center for Biotechnology Information.

Abudayyeh, Gootenberg and Koonin scanned genome sequences to learn more about the natural diversity of CRISPR systems and to exploit them for potential tools. The idea, says Abudayyeh, is to build on the work evolution has already done in engineering protein machines.

“We don’t know what we’re going to find,” Abudayyeh said, “but let’s just explore and see what’s out there.”

As the team scoured public databases to examine the components of different bacterial defense systems, a protein from a bacteria isolated from Tokyo Bay caught their attention. Its amino acid sequence indicated that it belonged to a class of CRISPR systems that use large multiprotein machines to find and cleave their targets. But this protein seemed to have everything it needed to do the job on its own. Other known single-protein Cas enzymes, including the Cas9 protein which has been widely adopted for DNA editing, belong to a distinct class of CRISPR systems, but Cas7-11 blurs the boundaries of the CRISPR classification system. , says Koonin.

The enzyme, which the team eventually named Cas7-11, was attractive from an engineering standpoint because unique proteins are easier to deliver to cells and are better tools than their complex counterparts. But its makeup also signaled an unexpected evolutionary history. The team found evidence that during evolution, components of a more complex Cas machine had fused together to form the Cas7-11 protein. Gootenberg equates this to the discovery of a bat when you previously assumed birds are the only animals that fly, thereby acknowledging that there are multiple evolutionary paths to flight. “It totally changes the landscape of how these systems are thought out, both functionally and evolutionarily,” he says.

Precision editing

When Gootenberg and Abudayyeh produced the Cas7-11 protein in their lab and started experimenting with it, they realized that this unusual enzyme offered a powerful way to manipulate and study RNA. When they introduced it into the cells with an RNA guide, it made remarkably precise cuts, cutting off its targets while leaving the other RNAs intact. This meant that they could use Cas7-11 to change specific letters in the RNA code, correcting errors introduced by genetic mutations. They were also able to program Cas7-11 to stabilize or destroy particular RNA molecules inside cells, which allowed them to adjust the levels of the proteins encoded by these RNAs.

Abudayyeh and Gootenberg also found that Cas7-11’s ability to cut RNA could be attenuated by a protein that appeared likely to also be involved in triggering programmed cell death, suggesting a possible link between CRISPR defense and a more extreme response to infection.

The team showed that a gene therapy vector can deliver the complete Cas7-11 editing system to cells and that Cas7-11 does not compromise cell health. They hope that with further developments, the enzyme could one day be used to edit disease-causing sequences from a patient’s RNA so that their cells can produce healthy proteins, or to reduce the level of disease. ‘a protein that causes harm due to a genetic disease. .

“We believe that the unique way Cas7-11 cuts allows for many interesting and diverse applications,” said Gootenberg, noting that no other CRISPR tool cuts RNA with such precision. “This is yet another excellent example of how these fundamental biology-driven explorations can produce new tools for therapy and diagnosis,” he adds. “And we are certainly still only scratching the surface of what exists in natural diversity.”


New CRISPR-Cas system cuts virus RNA


More information:
Ahsen Özcan et al, Programmable RNA Targeting with the Cas7-11 Single Protein CRISPR Effector, Nature (2021). DOI: 10.1038 / s41586-021-03886-5

Provided by the Massachusetts Institute of Technology

Quote: RNA Targeting Enzyme Extends CRISPR Toolkit (2021, September 20) retrieved September 20, 2021 from https://phys.org/news/2021-09-rna-targeting-enzyme-crispr-toolkit.html

This document is subject to copyright. Other than fair use for private study or research purposes, no part may be reproduced without written permission. The content is provided for information only.


Source link

]]>
https://e-jemed.org/rna-targeting-enzyme-extends-crispr-toolkit/feed/ 0
Shopping for new species | Hakai Magazine https://e-jemed.org/shopping-for-new-species-hakai-magazine/ https://e-jemed.org/shopping-for-new-species-hakai-magazine/#respond Mon, 20 Sep 2021 07:01:29 +0000 https://e-jemed.org/shopping-for-new-species-hakai-magazine/ Item body The fish tale is legendary. On December 23, 1938, South African museum curator Marjorie Courtenay-Latimer received a phone call from her friend Hendrik Goosen, a trawler captain who often let her look in the day’s catch for something special. Goosen had just returned with a new trait, featuring a very unusual large fish […]]]>

Item body

The fish tale is legendary. On December 23, 1938, South African museum curator Marjorie Courtenay-Latimer received a phone call from her friend Hendrik Goosen, a trawler captain who often let her look in the day’s catch for something special. Goosen had just returned with a new trait, featuring a very unusual large fish which he thought would pique Courtenay-Latimer’s interest. It certainly is. The fish – blue at the time of capture, but dark gray by the time Courtenay-Latimer arrived – looked primordial and had strange fleshy fins. Biologist JLB Smith later identified the fish as a coelacanth, a species believed to have been extinct for over 66 million years. It was like dipping a net in the ocean and dredging a plesiosaur.

In 1997, nearly 60 years after the rebirth of the coelacanth, a second species of coelacanth was spotted by biologists at a fish market in Sulawesi, Indonesia. This discovery and others like it have made fishermen and fish markets important sources of information for marine biologists eager to discover new species. The world’s oceans are so vast and deep that keeping an eye on what’s on the market can alert biologists to species they would likely be unable to spot or distinguish in the natural habitats of animals.

It can be a bit slippery, says Sarah Tucker, a researcher at the Hawai’i Institute of Marine Biology. “Markets can be difficult because the fish often come from different places and exchange hands between many different fish collectors,” she says.

Obtaining accurate and essential information about where a fish was caught can be difficult in such circumstances. Some researchers develop relationships with specific fishermen, just like Courtenay-Latimer, to help gain essential information about where the fish are caught. More than that, Tucker adds, “talking to local fishermen and fish collectors can be very helpful in understanding what they are observing and the local names of these species.”

Sometimes the presence of something new on a trawler or in a market is obvious. In 2018, marine biologists named a new species of deep sea shark, Planonasus indicus, which first caught the attention of researchers in a market near the southwest coast of India.

But many new species of fish are cryptic, difficult to distinguish based solely on anatomy. To get around this problem, biologists often study fish in markets using DNA barcodes, an effort that sometimes reveals previously unknown species, such as a new deep-water snapper named earlier this year. “It is becoming more and more common in scientific publications that you need both genetic and morphological analyzes,” says Tucker, genetic clues sometimes being the first clue that there is something new among the stalls. fish markets.

And biologists aren’t just interested in fish.

“We prefer to buy fish species that have not yet been intensively studied, or not at all, if our goal is to find new species of parasites,” says parasitologist Stefan Theisen of the University. from Rostock in Germany. The fact that fish tend to have species-specific parasites means that newer fish likely have new parasites, he adds, with specialists checking anatomical hotspots like the heart and esophagus for tiny hangers. Usually, Theisen adds, a sample of around 35 fish is needed to detect any parasites that might affect this species, which means a lot of time fishing among the stalls for something remarkable.


Source link

]]>
https://e-jemed.org/shopping-for-new-species-hakai-magazine/feed/ 0