Zymergen Announces Emerging Drug Discovery Activity Made Possible by One of the World’s Largest Metagenomics Databases and Proprietary Synthetic Biology Platform

Explore natural products for innovative therapies

SAN FRANCISCO, January 9, 2022 (GLOBE NEWSWIRE) – Biotech company Zymergen (ZY) announced new drug discovery activity based on its proprietary Synthetic Biology platform and what is considered the world’s largest metagenomics database, combining both size and quality. This new business takes advantage of Zymergen’s differentiated access to natural products as a source of diverse chemical materials and augments Zymergen’s existing advanced materials programs, capitalizing on years of previous research and development in synthetic biology.

Zymergen’s metagenomics database – which contains a breadth and depth of metagenomic information rivaling any publicly available dataset combined – provides access to a vast reservoir of new natural products, including molecules from uncultivated microbes. . Thanks to this resource, Zymergen scientists were able to confirm successful drugs and molecules currently on the market at the end of clinical development, and to discover new modulators of important oncological targets. By combining next-generation sequencing with proprietary machine learning and computing, Zymergen’s platform transforms the search for structurally new bioactive molecules from tedious screening campaigns into a fast and accurate digital database search for a therapeutic target of interest.

“Zymergen demonstrates the potential of a new discovery paradigm; move from ineffective large-scale physical screening to rapid screening in silico database research, which can dramatically accelerate the pace of early discovery, ”said Devin Scannell, vice president of innovation for Zymergen’s drug discovery business. “Whether for targeted protein degradation or traditional inhibitors, scientists are looking for access to a new chemical space. Our platform provides access to molecules that have evolved to engage targets of interest with very diverse mechanisms. In addition to great chemical novelty, the amount of optimization required to achieve drug-like properties for such molecules can be significantly less than for purely synthetic compounds.

Zymergen’s initial drug discovery pipeline is focused on high-value oncology targets where Zymergen’s precision medicine and distinctive complex molecules are expected to provide competitive and therapeutic advantages.

“We have sequenced and stored the equivalent of billions of previously unknown microbial genomes in a database that continues to grow,” said Oliver Liu, vice president of Metagenomics, Zymergen. “Compared to companies that have to rely on the same small slice of biodiversity that can be cultivated in the lab, we can use our patented process to access and unlock a source of new natural product discovery that has always been elusive. “

Zymergen’s position was strengthened by the acquisition of Lodo Therapeutics in mid-2021. Lodo Therapeutics brings additional expertise in metagenomics as well as an experienced team of drug discovery and proprietary technology, including for the design of drugs based on the structure of natural products. Their existing multi-target discovery collaboration with Genentech – part of the Roche group – continues to build on their previous achievements in preclinical stages.

“We are excited for the opportunity to make real breakthroughs in drug discovery with natural products,” said Jay Flatley, Interim CEO of Zymergen. “We believe that the size and diversity of our metagenomics collection – coupled with our unique bioinformatics tools and research capabilities – allow us to pursue ambitious and valuable goals. This is clearly a great choice for Zymergen as our strength in synthetic biology will give us an advantage in expressing these complex molecules, but ultimately we see this as a victory for patients in need of more effective treatments.

About Zymergen
Zymergen is a biotechnology company that designs and produces molecules, microbes and materials for various end markets. We partner with nature to make better products, a better way, for a better world.

Forward-looking statements
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. These forward-looking statements are based on the Company’s beliefs and assumptions and on the information currently available to it at the date of this press release. In some cases, you can identify these statements by forward-looking words such as “believe”, “may”, “may”, “aim”, “will”, “continue”, “anticipate”, “intend”, “Could,” “project”, “potential”, “opportunity”, “expect”, “designed to”, “focus” or the negative or plural of these or similar words. contained in this press release include, without limitation, statements regarding the potential of our drug discovery business and expectations regarding our metagenomics library. Forward-looking statements may involve known and unknown risks, uncertainties, and ” other factors that may cause actual results, performance or achievements to differ materially from those expressed or implied by forward-looking statements, including, but not limited to, risks relating to our ability to do business. read successfully or generate income from our products; our ability to develop or execute our new strategic plan; and our ability to reduce our operating costs and expand our cash flow path. These and other risks are described in more detail in documents filed by the Company with the SEC, including the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2021, and other documents. which the Company subsequently files with the SEC. Except to the extent required by law, the Company does not undertake in any way to update these statements to reflect events which occur or circumstances which exist after the date on which they were made.

Investor contact
Carrie Mendivil
[email protected]

Media contact
Mike Dulin
[email protected]


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